发给老马备查:8 V! F% l1 w; l0 z6 R$ v$ U
滴水察海(69304838) 15:23:23
. N9 F+ v8 y7 t9 n/ [" ~老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
; `) Y, |( C7 u. U+ U% J. k吉非替尼和S-1连用的依据
2 x( P& b. s, ~+ i v: L, rGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
0 ~4 K0 j6 J0 S/ u! d4 L& i3 T是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
+ C Y C2 E: C这样是不是推理出,耐药后,可以用S-1和培美了?
0 Z* H% g/ ]6 e9 I结论:
$ ?% ^7 g3 l1 ?) o N/ b" ^如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |