发给老马备查:7 s/ D& l% N1 f
滴水察海(69304838) 15:23:23# v4 s/ {5 _8 }
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱9 ?+ m6 m6 R; v0 {, G
吉非替尼和S-1连用的依据1 Z" ~& P+ M, o
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro., B: @. u+ ^; g9 ]* T% {3 l5 F& x
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
' J4 u! a& c6 D& @+ g2 ]这样是不是推理出,耐药后,可以用S-1和培美了?1 w: R+ h# t- R3 U
结论:
8 \/ X# e7 @3 ~% w- p3 `如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |